| Articles |  |
|
|
Determining Health Hazards: A Look into the EPA Practice
|
June 1, 2008
By:
Michael P. Balogh
|
|
 The matter of perfluorinated compounds (PFCs) came to focus at the United States Environmental Protection Agency (EPA) some eight years ago. |
|
Petroleomics — MS from the Ocean Floor
|
March 1, 2008
By:
Michael P. Balogh
|
|
 Recent work suggests that the practical value of hyphenated techniques is limited by difficulties inherent in achieving definitive compositional answers in general MS. This article argues that it is not impossible in certain cases. |
|
Hardware and Software Challenges for the Near Future: Structure Elucidation Concepts via Hyphenated Chromatographic Techniques
|
February 1, 2008
By:
Tobias Kind
, Oliver Fiehn
, Michael P. Balogh
|
|
 This month, guest columnists Kind and Fiehn discuss small-molecule structure elucidation (excluding peptides) using hyphenated chromatographic techniques, mass spectrometers, and other spectroscopic detectors. |
|
Incipient Technologies: Desorption and Thermal Desorption Techniques
|
December 1, 2007
By:
Michael P. Balogh
|
|
 Nearly a dozen incipient technologies have appeared in recent years. Which will survive? Which will find extensive, robust usage as did electrospray ionization? Which are fated to become footnotes in mass spectrometry practice? |
|
Collecting Wisdom
|
October 1, 2007
By:
Michael P. Balogh
|
|
| "As research advances, about half of what we will teach you . . . will turn out to be wrong. The problem is, we presently don't know which half." Powerful Medicines, Jerry Avorn, 2004 |
|
Techniques for Structure Elucidation of Unknowns: Finding Substitute Active Pharmaceutical Ingredients in Counterfeit Medicines
|
June 1, 2007
By:
Michael P. Balogh
|
|
 This month's column brings much of the previous discussion on how to interpret mass spectra to a practical examination of detecting substitutions in counterfeit pharmaceuticals. |
|
Alternatives in the Face of Chemical Diversity
|
April 1, 2007
By:
Michael P. Balogh
|
|
 In this month's "MS-The Practical Art," Michael Balogh takes a closer look at insight provided by Chuck McEwen regarding obstacles while using solvents. |
|
The Future of Drug Lead Development and Analysis
|
February 1, 2007
By:
Michael P. Balogh
|
|
 This month's installment of "MS - The Practical Art" reprises a talk from Chris Lipinski that examines the analytical road ahead in drug discovery and the quest to expand the chemistry landscape and its inherent analytical demands. |
|
Ionization Revisited
|
December 1, 2006
By:
Michael P. Balogh
|
|
 Over the last ten years or so, information gathered by applying atmospheric ionization techniques in mass spectrometry teaches us two things: 1) that liquid is a vestigial remnant of condensed-phase liquid chromatography and 2) that solvent in the gas phase limits ionization to molecules that are more basic than the solvent. |
|
