Jun 1, 2008
By:
Tim Wehr
|
This installment of "Directions in Discovery" will review current phosphorylation enrichment techniques with a focus on new developments.
Mar 1, 2008
By:
Tim Wehr
|
In the last year, two new protein depletion products have been introduced, and these will be the focus of this month's installment of "Directions in Discovery."
Quantitative assessment of protein expression in biological systems in response to perturbations is an important element in the discovery and validation of biomarkers and drug targets. This can be a challenging task given the complexity and dynamic range of biological extracts. Many methods are currently in use to address protein quantification. This installment of "Directions in Discovery" reviews several of the more popular ones and reports on a collaborative study organized by the Association of..
Oct 1, 2007
By:
Tim Wehr
|
Quantitative assessment of protein expression in biological systems in response to perturbations is an important element in the discovery and validation of biomarkers and drug targets. This can be a challenging task given the complexity and dynamic range of biological extracts. Many methods are currently in use to address protein quantification. This installment of "Directions in Discovery" reviews several of the more popular ones and reports on a collaborative study organized by the Association of Biomolecular Resource Facilities.
Mar 1, 2007
By:
Klara Valko
|
Fast, reliable measurements of lipophilicity has a great impact on the compounds' selection process at an early stage of dug discovery. The guest columnit examines HPLC methods for this purpose.
Top-down and bottom-up are alternative strategies for protein identification and characterization by mass spectrometry. How do they fit into the world of proteomics? What are their implications for separation technology? These questions are addressed in this installment of "Directions in Discovery."
Top-down and bottom-up are alternative strategies for protein identification and characterization by mass spectrometry. How do they fit into the world of proteomics? What are their implications for separation technology? These questions are addressed in this installment of "Directions in Discovery."
Sep 1, 2006
By:
Tim Wehr
|
September 2006. Top-down and bottom-up are alternative strategies for protein identification and characterization by mass spectrometry. How do they fit into the world of proteomics? What are their implications for separation technology? These questions are addressed in this installment of "Directions in Discovery."
May 1, 2006
By:
Caitlin McEathrom, Tim Wehr
|
This is the second installment of a two-part series on the practical aspects of configuring and operating a nano liquid chromatography-mass spectrometry (LC-MS) system.
Mar 1, 2006
By:
Caitlin McEathron, Tim Wehr
|
The first of a two-part series addresses HPLC pumps, sample introduction systems, and columns for nanoLC-MS.
