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Peak Shape Problems
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July 1, 2008
By:
John W. Dolan
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 This month's column will consider two problem areas; peaks that have severely tailing peaks, or split or doubled peaks, and the peaks that front badly. |
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How Do I . . . ?
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May 1, 2008
By:
John W. Dolan
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 For this month's discussion, John Dolan shares some of the key resources that he recommends using when you have one of those "How do I?" questions. |
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Only Three Things
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April 1, 2008
By:
John W. Dolan
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 After taking a course on learning that stated most people only remember three main points from an eight-hour training class, John Dolan decided to use three points to form the core of a preventive maintenance program for your LC system. |
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Method Transfer Problems
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March 1, 2008
By:
John W. Dolan
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 After teaching a training class in China, John Dolan was reminded of how chromatographers worldwide encounter the same types of problems, such as method transfer. This month's column is dedicated to method transfer problems. |
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Ion Pairing - Blessing or Curse?
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February 1, 2008
By:
John W. Dolan
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 Reversed-phase liquid chromatography (LC) is a simple and easy-to-use technique that will give satisfactory separations for the samples that most of us encounter. Here, John Dolan examines the pros and cons of this technique. |
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Flow Rate Adjustment and System Suitability
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January 1, 2008
By:
John W. Dolan
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 This month's "LC Troubleshooting" installment examines the possible reasons your retention times could have changed. If the root cause can be identified and corrected, no adjustment in flow rate will be necessary. |
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The Perfect Method, Part VII: The Gradient Shortcut
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December 1, 2007
By:
John W. Dolan
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 For the last six months, "LC Troubleshooting" has been concentrating on the process for the development of isocratic methods (those for which the mobile phase composition is constant throughout the run). The use of a gradient scouting run to speed isocratic method development is the subject of this month?s "LC Troubleshooting." |
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The Perfect Method, Part VI: Make it Faster
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November 1, 2007
By:
John W. Dolan
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| In the previous installments of this series on efficient development of LC methods (1?5), we have concentrated on improving resolution by modifying the mobile phase, choosing a different stationary phase, or changing some other condition, such as column temperature. In this month?s "LC Troubleshooting" installment, we take a look at trading some of that resolution for a faster separation. |
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The Perfect Method, V: Changing Column Selectivity
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October 1, 2007
By:
John W. Dolan
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| How to avoid an expensive shot in the dark. |
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