In chiral preparative supercritical fluid chromatography, samples are often over-loaded and it is difficult to determine when to start and end fractionation from UV chromatographic data. A circular dichroism detector can differentiate enantiomers and generate positive?negative responses arising from eluted chromatographic peaks.

Basic information on stereochemistry is provided in this article to help readers develop a better understanding of the separation mechanisms that come into play in various separation methods used for chiral compounds. This knowledge can allow readers to select a desirable chiral separation method, based upon the molecular structure of the chiral compound of interest. Logical reasons for the selection process are discussed later in this article.

The Pittsburgh Conference has announced that advance registration is now open for Pittcon 2008.

Chiral Technologies Inc., a provider of chiral chromatography columns, has announced that it will expand Latin American sales efforts by partnering with exclusive distributors.

System Suitability and Validation for Chiral Purity Assays of Drug Substances Nov 1, 2006 By: P.W. Wrezel, I. Chion, R. Pakula, D.W. Weissmueller

Measurement of chiral purity is a necessary means of quality control for drug substances that exhibit chiral centers. This article describes a simple and practical approach to setting up system suitability and validation for chiral purity assays.