Shimadzu Scientific Instruments (Columbia, Maryland) and Groton Biosystems (Boxborough, Massachusetts) recently announced a collaboration effort to interface Groton’s online sampling monitors with Shimadzu’s high performance liquid chromatography (HPLC) system to form a closed-loop solution for online analysis.

Quantitative assessment of protein expression in biological systems in response to perturbations is an important element in the discovery and validation of biomarkers and drug targets. This can be a challenging task given the complexity and dynamic range of biological extracts. Many methods are currently in use to address protein quantification. This installment of "Directions in Discovery" reviews several of the more popular ones and reports on a collaborative study organized by the Association of Biomolecular Resource Facilities.