Column Care Aug 1, 2008 By: John W. Dolan

After returning from Israel, John Dolan dedicates this month's column discussion to three problems that know no international boundaries: how to condition a new column, the effect of washing a column with water, and ...

Peak Shape Problems Jul 1, 2008 By: John W. Dolan

This month's column will consider two problem areas; peaks that have severely tailing peaks, or split or doubled peaks, and the peaks that front badly.

Check Valves and Acetonitrile Jun 1, 2008

John Dolan has discovered that check-value problems have jumped to the top of the list with LC users. He takes a look at them in this month's installment of "LC Troubleshooting."

How Do I . . . ? May 1, 2008 By: John W. Dolan

For this month's discussion, John Dolan shares some of the key resources that he recommends using when you have one of those "How do I?" questions.

Ion-pair chromatography can be your best friend or your worst enemy.

Only Three Things Apr 1, 2008 By: John W. Dolan

After taking a course on learning that stated most people only remember three main points from an eight-hour training class, John Dolan decided to use three points to form the core of a preventive maintenance program for your LC system.

If the problem source cannot be found or if found, cannot be corrected, an adjustment in flow-rate is justified.

Method Transfer Problems Mar 1, 2008 By: John W. Dolan

After teaching a training class in China, John Dolan was reminded of how chromatographers worldwide encounter the same types of problems, such as method transfer. This month's column is dedicated to method transfer problems.

A very efficient way to start an isocratic method development project is to make the first run as a scouting gradient run.