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LCxLC: Comprehensive Two-Dimensional Liquid Chromatography
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July 1, 2008
By:
Peter Schoenmakers
, Ronald E. Majors
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 Guest Editor Peter Schoenmakers provides an introduction to LCxLC, and then goes on to talk about peak capacity, sample dimensionality, phase orthogonality, and some of the successes of the technique and the obstacles yet to be overcome. |
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Comparison Techniques For HPLC Column Performance
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June 1, 2008
By:
Gert Desmet
, Ronald E. Majors
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 Guest columnsist and LCGC Emerging Leader award recipient Gert Desmet considers the different methods that can be used to compare the performance of LC columns. |
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Developments in HPLC Column Technology (2006–2008)
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April 1, 2008
By:
Ronald E. Majors
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| In the leadoff article, columnist Ron Majors provides an overview of column developments. He looks at various alternatives to high-throughput separations including small porous particles, monoliths and superficially-porous particles. Microfluidics and parallel column systems provide further alternatives. An alternative approach to isocratic method development uses optimized stationary phase combinations. Brief coverage of new phases for hydrophilic interaction chromatography, high temperature operation, chiral and mixed mode columns and finally supercritical fluid chromatography columns round out the overview. At the conclusion, Majors speculates on future directions in column technology. |
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New Chromatography Columns and Accessories at Pittcon 2008: Part II
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April 1, 2008
By:
Ronald E. Majors
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 This month's installment of "Column Watch" is the second part of a two-part series in which columnist Ron Majors examines the trends and highlights in columns and consumables at Pittcon 2008. |
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Introduction: HPLC Column Technology – State of the Art
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April 1, 2008
By:
Ronald E. Majors
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| It has often been stated (or maybe overstated) that the column is the heart of the chromatograph. Without the proper choice of column and appropriate operating conditions, method development and optimization of the high performance liquid chromatographic (HPLC) separation can be frustrating and unrewarding experiences. Since the beginning of modern liquid chromatography, column technology has been a driving force in moving separations forward. Today, the driving forces for new column configurations and phases are the increased need for high throughput applications, for high sensitivity assays and to characterize complex samples such as peptide digests and natural products. |
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New Chromatography Columns and Accessories at Pittcon 2008: Part I
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March 1, 2008
By:
Ronald E. Majors
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 This month's installment of "Column Watch" is the first of a two-part series in which columnist Ron Majors examines the trends and highlights in columns and consumables at Pittcon 2008. |
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Glossary of HPLC/LC Separation Terms
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February 1, 2008
By:
Ronald E. Majors
, Peter W. Carr
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 In 2001, the second glossary of common and not-so-common terms and "buzz words" for reference to HPLC columns and column technology was published. It is time for an update since new terms have arisen or, in some cases, their original meanings have expanded or changed. |
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Approaches to High-Speed Separations in HPLC
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January 1, 2008
By:
Ronald E. Majors
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 In this installment of "Column Watch," Ron Majors examines the various approaches to increasing the speed of high performance liquid chromatography (HPLC) separations. |
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Immunosorbents for Selective Sample Preparation of Complex Mixtures
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December 1, 2007
By:
Ronald E. Majors
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 In this month?s installment, columnist Ron Majors covers the field of immunoextraction, a technique that employs immobilized antibodies to selectively capture specific analytes using molecular recognition via antibody?antigen interactions. Recently, the introduction of commercial products for specific high-volume environmental and food safety applications has spurred further applications of this technique. |
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