Peak Shape Problems Jul 1, 2008 By: John W. Dolan

This month's column will consider two problem areas; peaks that have severely tailing peaks, or split or doubled peaks, and the peaks that front badly.

LCxLC: Comprehensive Two-Dimensional Liquid Chromatography Jul 1, 2008 By: Peter Schoenmakers, Ronald E. Majors

Guest Editor Peter Schoenmakers provides an introduction to LCxLC, and then goes on to talk about peak capacity, sample dimensionality, phase orthogonality, and some of the successes of the technique and the obstacles yet to be overcome.

A Shock to the System Jul 1, 2008 By: John V. Hinshaw

This month in "GC Connections," in the first of a two-part series, John Hinshaw relates what happens when high-voltage spikes attack modern electronic equipment, what to do when they occur, and more.

From Academician to Entrepreneur — A Convoluted Trek Jul 1, 2008 By: Walt Jennings

Walt Jennings briefly sketches a path, occasionally humorous, occasionally somber, from the time of his Ph.D. candidacy in 1953 to the present day.

A Hydrophilic Interaction Chromatography Method for the Purity Analysis of Cytosine Jul 1, 2008 By: Mark Strege, Charles Durant, John Boettinger, Michael Fogarty

The authors meet the need for a method for the determination of cytosine purity by developing a hydrophilic interaction chromatography (HILIC) method with demonstrated advantages in comparison to other separation techniques.

Enriching the Phosphoproteome Jun 1, 2008 By: Tim Wehr

This installment of "Directions in Discovery" will review current phosphorylation enrichment techniques with a focus on new developments.

Inside the Personalized Medicine Toolbox: GCxGC-Mass Spectrometry for High-Throughput Profiling... Jun 1, 2008 By: Adam W. Culbertson, W. Brent Williams, Andrew G. Mckee, Xiang Zhang, Keith L. March, Stephen Naylor, Stephen J. Valentine

The authors present results that suggest that high-throughput, high-coverage profiling capabilities, such as those afforded by GCxGC-TOF-MS, can impact the development of personalized medicine.

Comparison Techniques For HPLC Column Performance Jun 1, 2008 By: Gert Desmet, Ronald E. Majors

Guest columnsist and LCGC Emerging Leader award recipient Gert Desmet considers the different methods that can be used to compare the performance of LC columns.

Determining Health Hazards: A Look into the EPA Practice Jun 1, 2008 By: Michael P. Balogh

The matter of perfluorinated compounds (PFCs) came to focus at the United States Environmental Protection Agency (EPA) some eight years ago.