Analytical Method Validation in Proteomics and Peptidomics Studies Nov 1, 2008 By: Ira Krull, P.T. Kissinger, Michael Swartz

While the "Validation Viewpoint" column has focused on conventional and recombinant pharmaceutical products, and at times, bioanalytical methods, we have just begun to think about method validation as it relates to -omics type studies.

Frequently Asked Questions about Hydrogen Carrier Gas Nov 1, 2008 By: John V. Hinshaw

In this installment of "GC Connections," John Hinshaw addresses some of the more frequently asked questions he encounters about hydrogen as carrier gas.

The Role of Polymers in Solid-Phase Extraction and Sample Preparation Nov 1, 2008 By: Ronald E. Majors

This installment of SPP will compare and contrast the various types of polymeric and non-polymeric sorbents. The major advantages or polymeric sorbents will be discussed, and some applications will illustrate the versatility of polymeric SPE.

Biomonitoring: Polybrominated Diphenyl Ethers and Polybrominated Biphenyls Using Capillary GC with Electron... Nov 1, 2008 By: Paul R. Loconto

A selective and highly sensitive capillary gas chromatographic-mass spectromic approach has been developed for the detection of PBDEs and PBBs that utilizes dissociative resonance electron capture and selected ion monitoring.

Extracolumn Effects Nov 1, 2008 By: John W. Dolan

All the buzz lately about LC columns packed with particles smaller than 3 mm often comes with warnings about extracolumn effects. This month's installment will take a look at what these effects are and more.

Drip, Drip, Drip . . . Oct 1, 2008 By: John W. Dolan

This "LC Troubleshooting" installment marks the beginning of the 26th year that John Dolan has written this column.

Kurt Grob — One of the Fathers of Capillary GC Oct 1, 2008 By: Koni Grob

In this month's installment, Kurt Grob's life and achievements are described by someone who knew him like few other people did: his son, Koni Grob.

A Mass Spectrometry Primer, Part II Oct 1, 2008 By: Michael P. Balogh

Part II of this three-part series focuses on comparing operation and performance of the most well known mass spectrometers.

Review and Optimization of Linearity and Precision in Quantitative HPLC–ELSD with Chemometrics Oct 1, 2008 By: Ira S. Krull, Steven Walfish, Wayne O. Aruda

HPLC with ELSD continues to grow in popularity as a "quasi- universal" detector. Improvements in ELSD instrument design, including low temperature evaporation, have recently been commercialized...